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Pharmacovigilance & Drug Safety

Scientific Expertise. Regulatory Discipline. Global PV Operations.

Our Services

Comprehensive Support for Patient Safety

VIGIVANCE delivers end-to-end pharmacovigilance and drug safety services, combining scientific rigour, regulatory discipline and continuous oversight across global markets.

End-to-end pharmacovigilance and drug safety support designed to maintain compliant, effective and inspection-ready safety systems across global markets, built on scientific rigour and continuous regulatory alignment.

ICSR ManagementSafety SurveillanceLiterature MonitoringSignal ManagementPSUR/PBRERRMPPSMFQPPV/LQPPV SupportSafety Governance
11 PV Capability Areas

11 PV Capability Areas

Full Capability Set

The PV Capability Areas We Cover

Eleven core areas, delivered under one accountable team, from first case intake through to signal closure and inspection readiness.

Every case enters a structured, validated workflow from first receipt, so downstream assessment, coding and reporting always build on accurate, audit-ready data.

Case Intake & BookingCase Triage & Validity AssessmentICSR Data Entry & ProcessingSeriousness & Expectedness AssessmentMedDRA CodingCase Narrative PreparationFollow-up & Case ManagementDuplicate AssessmentPeer Review & Quality ControlPhysician / Medical ReviewExpedited Reporting SupportCase ReconciliationCase Closure & Archiving

We build and maintain the PSMF and the wider PV system behind it, keeping documentation current, defensible and ready for review at any time.

New PSMF PreparationPSMF Maintenance & Periodic UpdatesLocal / Country-Specific PV DocumentationPV System DescriptionPV Process & Responsibility MappingPV System GAP AssessmentPV Compliance AssessmentCAPA Development & Remediation SupportSupporting Documentation & Annex ManagementAudit & Inspection ReadinessPV Training & System Support

Named QPPV and deputy support gives your programme a single point of safety accountability, with oversight extended consistently across every market.

QPPV / Deputy QPPV SupportLocal PV OversightPV System OversightSafety GovernanceSafety Profile OversightCompliance MonitoringReview of Safety InformationRegulatory Safety Communication SupportHealth Authority Liaison SupportPV Agreement OversightEscalation & Issue ManagementManagement Reporting

Systematic screening of global and local literature surfaces safety-relevant information early, so nothing material to your product's profile is missed.

Global Literature ScreeningLocal / Country-Specific Literature ScreeningScientific & Medical Literature ReviewAdverse Event IdentificationPotential Safety Signal IdentificationMedical Literature MonitoringLiterature Case AssessmentDuplicate AssessmentFull-Text Article RetrievalLiterature Case ProcessingTranslation CoordinationLiterature Reconciliation & Documentation

Periodic and aggregate safety reports are prepared with rigorous data reconciliation and medical review, giving health authorities a clear, evidence-based view of your product's benefit-risk profile.

PSUR | PBRER | Aggregate Safety Assessment, supporting global products across diverse regulatory markets.

PSUR PreparationPBRER PreparationPeriodic Safety Data ReviewCumulative Safety Data AnalysisBenefit–Risk EvaluationSignal Information IntegrationSafety Concern EvaluationRegulatory Submission SupportLocal Aggregate Report SupportData ReconciliationMedical & Scientific ReviewQuality Control & Finalisation

Signals are detected, validated and prioritised against multiple data sources, then carried through medical review to a documented, actionable outcome.

Data-led analysis. Expert medical interpretation. Actionable safety assessment.

Signal DetectionSignal Identification & ValidationSignal PrioritisationSignal EvaluationReview of Multiple Safety Data SourcesHistorical / Legacy Data ReviewSignal Evaluation Report PreparationMedical & Scientific ReviewSignal Tracking & DocumentationQPPV / SME Review SupportRegulatory Assessment SupportSignal Follow-up & Closure

Core and local RMPs are developed and kept current, with risk minimisation measures tracked through to measurable effectiveness.

Risk Management Plan (RMP) PreparationCore & Local RMP SupportSafety Concern IdentificationAdditional Risk Minimisation Measures (aRMMs)Educational Material SupportRisk Minimisation Measure TrackingEffectiveness EvaluationBenefit–Risk AssessmentRMP Updates & Maintenance

Ongoing GAP and compliance assessment, paired with structured CAPA tracking, keeps your PV system inspection-ready every day, not only before an audit.

PV System GAP AssessmentPV Compliance AssessmentProcess & Documentation ReviewSOP Development & ReviewCAPA Development & TrackingPV Audit SupportVendor / Partner OversightPV Agreement ReviewCompliance MonitoringTraining & AwarenessInspection ReadinessQuality Oversight

SDEAs and PV agreements are drafted, reviewed and maintained with clear responsibility mapping, so obligations across every partner stay traceable.

Safety Data Exchange Agreements (SDEA)PV Agreement DevelopmentAgreement Review & Gap AssessmentPartner Responsibility MappingPV Due Diligence SupportReconciliation & Compliance MonitoringPartner TrainingVendor OversightAgreement Maintenance & Updates

Digital case workflows, dashboards and reconciliation tools bring structure and traceability to safety data management, end to end.

PV Database SolutionsDigital Case Management WorkflowsElectronic Case TrackingReconciliation WorkflowsPV Dashboards & ReportingData Quality MonitoringWorkflow ManagementManagement Information & AnalyticsData Review & Reporting Support

Dedicated EU QPPV and GVP-aligned support covers the full scope of EudraVigilance, aggregate reporting and signal management obligations.

EU QPPV ServicesPSMF ServicesEudraVigilance Services (E2B(R3), reconciliation)EU Literature MonitoringPSUR / PBRER Preparation & SubmissionEU Signal ManagementEU Risk Management & RMPsGVP Compliance, Audits & CAPASDEA & PV Agreement Oversight

Aggregate Reporting, Built for Global Submission

We prepare PSUR and PBRER submissions with rigorous data reconciliation and medical review at every stage, so the finished report withstands scrutiny in any market.

Cumulative safety data is assessed against the product's evolving benefit-risk profile, with signal information integrated directly into the narrative rather than treated as a separate exercise.

Signal Management, From Detection to Closure

Our signal management process combines systematic detection with expert medical interpretation, reviewing multiple safety data sources rather than relying on a single feed.

Every signal is tracked through validation, evaluation and regulatory assessment to a documented, defensible closure.

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End-to-End Pharmacovigilance, From Case Intake to Signal Closure

Core PV capability areas delivered under one accountable team.

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The Rest of Our Integrated Service Offering

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